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Keep track of Carefully (one)pentobarbital will decrease the level or result of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to your reduce in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly